Which statement is true about tadalafil?

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Multiple Choice

Which statement is true about tadalafil?

Explanation:
Tadalafil works by inhibiting phosphodiesterase type 5, the enzyme that hydrolyzes cyclic GMP in smooth muscle. In penile tissue, nitric oxide released during sexual stimulation increases cGMP, which relaxes the smooth muscle and allows more blood to flow into the corpus cavernosum. By blocking PDE5, tadalafil prolongs the cGMP signal, enhancing and sustaining an erection in response to arousal. It is selective for PDE5 over other PDEs, which is why its primary effect is on erectile tissue with fewer widespread effects (though some minor visual changes can occur from limited PDE6 inhibition). It does not cause an erection without sexual stimulation, and it should not be used with nitrates due to risk of severe hypotension. So the true statement is that tadalafil inhibits PDE5.

Tadalafil works by inhibiting phosphodiesterase type 5, the enzyme that hydrolyzes cyclic GMP in smooth muscle. In penile tissue, nitric oxide released during sexual stimulation increases cGMP, which relaxes the smooth muscle and allows more blood to flow into the corpus cavernosum. By blocking PDE5, tadalafil prolongs the cGMP signal, enhancing and sustaining an erection in response to arousal. It is selective for PDE5 over other PDEs, which is why its primary effect is on erectile tissue with fewer widespread effects (though some minor visual changes can occur from limited PDE6 inhibition). It does not cause an erection without sexual stimulation, and it should not be used with nitrates due to risk of severe hypotension. So the true statement is that tadalafil inhibits PDE5.

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