Which statement correctly matches tadalafil with its functional class?

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Multiple Choice

Which statement correctly matches tadalafil with its functional class?

Explanation:
PDE5 inhibition prolongs the action of cGMP in response to nitric oxide, which is essential for penile erection. During sexual stimulation, nitric oxide increases cGMP in smooth muscle of the penis, causing relaxation and increased blood flow. Phosphodiesterase type 5 breaks down cGMP, limiting this effect. By inhibiting PDE5, tadalafil prevents cGMP breakdown, sustaining smooth muscle relaxation and facilitating erection. The other mechanisms described would either raise cAMP (adenylate cyclase activator), lower cGMP (guanylate cyclase inhibitor), or involve a different PDE family (PDE1), none of which match tadalafil’s action. Hence, tadalafil is a PDE5 inhibitor.

PDE5 inhibition prolongs the action of cGMP in response to nitric oxide, which is essential for penile erection. During sexual stimulation, nitric oxide increases cGMP in smooth muscle of the penis, causing relaxation and increased blood flow. Phosphodiesterase type 5 breaks down cGMP, limiting this effect. By inhibiting PDE5, tadalafil prevents cGMP breakdown, sustaining smooth muscle relaxation and facilitating erection. The other mechanisms described would either raise cAMP (adenylate cyclase activator), lower cGMP (guanylate cyclase inhibitor), or involve a different PDE family (PDE1), none of which match tadalafil’s action. Hence, tadalafil is a PDE5 inhibitor.

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