Which statement best describes zuranolone's relation to allopregnanolone?

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Multiple Choice

Which statement best describes zuranolone's relation to allopregnanolone?

Explanation:
Zuranolone acts as a positive allosteric modulator of the GABA-A receptor, similar to allopregnanolone. It binds to the neurosteroid site on the receptor and enhances the effect of GABA, increasing chloride flux and strengthening inhibitory signaling, but it does not activate the receptor by itself. This means it amplifies GABA’s action rather than serving as a direct GABA receptor agonist. So, zuranolone’s relation to allopregnanolone is that it mimics its role as a PAM of the GABA-A receptor. It is not about inhibiting production and it is clearly related to GABA receptors.

Zuranolone acts as a positive allosteric modulator of the GABA-A receptor, similar to allopregnanolone. It binds to the neurosteroid site on the receptor and enhances the effect of GABA, increasing chloride flux and strengthening inhibitory signaling, but it does not activate the receptor by itself. This means it amplifies GABA’s action rather than serving as a direct GABA receptor agonist. So, zuranolone’s relation to allopregnanolone is that it mimics its role as a PAM of the GABA-A receptor. It is not about inhibiting production and it is clearly related to GABA receptors.

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