Which sequence best describes the relationship between obesity and type 2 diabetes?

• A. Excess fats/sugars → insulin resistance → increased glucagon signals liver to release glucose → elevated blood glucose
• B. Diet alone cures diabetes
• C. Type 2 diabetes causes obesity by lipolysis envy
• D. There is no link between obesity and glucose regulation

Answer: (A)

Obesity tends to raise circulating fatty acids and inflammatory signals that interfere with how insulin works in key tissues. This creates insulin resistance, especially in muscle and liver, so glucose isn’t taken up as effectively and the liver keeps producing glucose. In this setting, glucagon’s effect on the liver can also be more pronounced or inadequately checked, pushing hepatic glucose output higher. The combination of reduced glucose uptake and increased hepatic glucose release drives elevated blood glucose, which is a hallmark of type 2 diabetes. So the sequence that shows excess fats/sugars leading to insulin resistance, then more glucose being released by the liver, and finally higher blood glucose best describes the relationship.

The other ideas aren’t accurate representations of the relationship. Diet alone does not cure diabetes, obesity’s link to glucose regulation is real, and the notion that obesity causes diabetes via a nonsensical lipolysis-based mechanism isn’t supported by how insulin resistance and hepatic glucose production work in this condition.