Which option is NOT listed as a side effect of semaglutide?

• A. Hypertension
• B. Nausea
• C. Gallbladder disease
• D. Bone density reduction

Answer: (A)

Semaglutide’s adverse effect profile centers on effects driven by its GLP‑1 receptor mechanism: gastrointestinal symptoms from slowed gastric emptying (nausea, vomiting, diarrhea, abdominal pain) and an increased risk of gallbladder problems such as gallstones or cholecystitis, which have been observed in trials and noted in labeling. Blood pressure changes, including hypertension, are not listed as a typical adverse effect of semaglutide. While blood pressure may vary for other reasons during treatment or due to comorbidities, the drug itself is not known for causing hypertension as a standard side effect. Bone density changes are not a common, well-established adverse effect either, so the clearest not-listed option in standard references is hypertension.