Which of the following is a side effect of tadalafil?

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Multiple Choice

Which of the following is a side effect of tadalafil?

Explanation:
Headache is a common side effect of tadalafil because this drug inhibits PDE5, boosting cGMP and causing smooth muscle relaxation and vasodilation. This vasodilatory effect can occur in cerebral vessels, leading to headaches in many patients. While other effects like flushing or nasal congestion can accompany PDE5 inhibitors, increased appetite is not typical, a cough is not commonly linked, and rash is less common than headaches. So headaches best explain the side effect profile of tadalafil.

Headache is a common side effect of tadalafil because this drug inhibits PDE5, boosting cGMP and causing smooth muscle relaxation and vasodilation. This vasodilatory effect can occur in cerebral vessels, leading to headaches in many patients. While other effects like flushing or nasal congestion can accompany PDE5 inhibitors, increased appetite is not typical, a cough is not commonly linked, and rash is less common than headaches. So headaches best explain the side effect profile of tadalafil.

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