Which immune cells destroy B lymphocytes after Ocrelizumab tags them via CD20?

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Multiple Choice

Which immune cells destroy B lymphocytes after Ocrelizumab tags them via CD20?

Explanation:
The main idea is antibody-dependent cellular cytotoxicity. Ocrelizumab binds to CD20 on B cells, coating them with IgG. Natural killer cells have Fc receptors (CD16, FcγRIII) that recognize the Fc portion of these antibodies. When NK cells engage the antibody-coated B cells, they release cytotoxic granules to kill the target—a process known as ADCC. This makes NK cells the primary effector population responsible for destroying B lymphocytes in this scenario. While macrophages can phagocytose opsonized cells and complement can lyse them, the direct cytotoxic destruction driven by NK cells best fits the question.

The main idea is antibody-dependent cellular cytotoxicity. Ocrelizumab binds to CD20 on B cells, coating them with IgG. Natural killer cells have Fc receptors (CD16, FcγRIII) that recognize the Fc portion of these antibodies. When NK cells engage the antibody-coated B cells, they release cytotoxic granules to kill the target—a process known as ADCC. This makes NK cells the primary effector population responsible for destroying B lymphocytes in this scenario. While macrophages can phagocytose opsonized cells and complement can lyse them, the direct cytotoxic destruction driven by NK cells best fits the question.

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