Which feature enables zuranolone to reach GABA receptors in the brain?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Study for the Pharmacology Presentation Drugs Test. Delve into flashcards and multiple choice questions with hints and explanations. Gear up for examination success!

Multiple Choice

Which feature enables zuranolone to reach GABA receptors in the brain?

Explanation:
Crossing the blood-brain barrier by passive diffusion, which is favored by high lipophilicity, is what lets zuranolone reach GABA receptors in the brain. Zuranolone is designed to be highly lipophilic, so it readily diffuses through the lipid membranes of brain capillaries to reach GABA-A receptors and modulate this inhibitory signaling. If a drug is hydrophilic or very large, it won’t cross easily, and relying on active transport would require specific transporters (which isn’t the primary route here).

Crossing the blood-brain barrier by passive diffusion, which is favored by high lipophilicity, is what lets zuranolone reach GABA receptors in the brain. Zuranolone is designed to be highly lipophilic, so it readily diffuses through the lipid membranes of brain capillaries to reach GABA-A receptors and modulate this inhibitory signaling. If a drug is hydrophilic or very large, it won’t cross easily, and relying on active transport would require specific transporters (which isn’t the primary route here).

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy