Which drug is a monoclonal antibody used to treat MS?

• A. Tadalafil
• B. Empagliflozin
• C. Adalimumab
• D. Ocrelizumab

Answer: (D)

Monoclonal antibodies can target specific components of the immune system to reduce autoimmune inflammation. In MS, a monoclonal antibody that targets CD20 on B cells depletes these cells and lowers their contribution to CNS inflammation. This mechanism helps lessen relapses and slow disability progression, and it’s approved for both relapsing forms of MS and primary progressive MS.

The other options are not used for MS for good reasons: a PDE5 inhibitor and an SGLT2 inhibitor are small-molecule drugs with different targets and indications, while there is a monoclonal antibody in the list that targets TNF-α but is not used for MS because it can worsen demyelinating diseases. Therefore, the drug that fits the question is the anti-CD20 monoclonal antibody used in MS.