Which cardiac function is most directly impaired by ATTR-related ventricular stiffening?

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Multiple Choice

Which cardiac function is most directly impaired by ATTR-related ventricular stiffening?

Explanation:
Ventricular stiffening from ATTR amyloid deposition makes the ventricle noncompliant, so it cannot relax and expand well during diastole. Filling therefore becomes impaired, raising filling pressures and leading to diastolic dysfunction with typically preserved systolic ejection early on. While conduction abnormalities and changes in coronary perfusion can occur with infiltration, the direct, most pronounced effect of the stiff ventricle is reduced diastolic filling.

Ventricular stiffening from ATTR amyloid deposition makes the ventricle noncompliant, so it cannot relax and expand well during diastole. Filling therefore becomes impaired, raising filling pressures and leading to diastolic dysfunction with typically preserved systolic ejection early on. While conduction abnormalities and changes in coronary perfusion can occur with infiltration, the direct, most pronounced effect of the stiff ventricle is reduced diastolic filling.

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