What is the effect of PDE5 inhibition on cGMP levels?

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Multiple Choice

What is the effect of PDE5 inhibition on cGMP levels?

Explanation:
Blocking PDE5 prevents the breakdown of cGMP, so its levels rise. This boosts the NO-driven signaling that relaxes smooth muscle, leading to vasodilation. In other words, PDE5 inhibitors increase cGMP. If cGMP were to decrease or stay the same, it would imply enhanced degradation or no effect, which isn’t how PDE5 inhibitors work. The result you’d expect is a higher, not lower or unchanged, cGMP level.

Blocking PDE5 prevents the breakdown of cGMP, so its levels rise. This boosts the NO-driven signaling that relaxes smooth muscle, leading to vasodilation. In other words, PDE5 inhibitors increase cGMP. If cGMP were to decrease or stay the same, it would imply enhanced degradation or no effect, which isn’t how PDE5 inhibitors work. The result you’d expect is a higher, not lower or unchanged, cGMP level.

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