What is a major limitation of semaglutide?

• A. Causes irreversible kidney damage
• B. Weight regain occurs after stopping treatment
• C. Stops working after one week
• D. Permanently reduces body fat

Answer: (B)

Weight regain after stopping semaglutide is a major limitation. Semaglutide lowers appetite and helps with weight loss while you’re taking it, but the effects fade when the medication is discontinued. Without continued therapy and compatible lifestyle changes, most people tend to regain much of the lost weight as appetite returns to baseline. This means long-term or ongoing treatment is typically needed to maintain weight loss. The other statements don’t fit: there isn’t a known irreversible kidney damage as a major limitation, the drug doesn’t stop working after one week because it’s long-acting with weekly dosing, and it doesn’t permanently reduce body fat—weight loss isn’t maintained without ongoing treatment.