What happens when zuranolone binds to GABA receptors?

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Multiple Choice

What happens when zuranolone binds to GABA receptors?

Explanation:
Zuranolone is a positive allosteric modulator of GABA-A receptors. The GABA-A receptor is a ligand-gated chloride channel; when GABA binds, the channel opens and chloride ions enter the neuron, producing inhibition. Zuranolone binds to an allosteric site and increases the probability (or duration) that the channel opens in response to GABA. This boosts chloride influx and enhances GABAergic inhibition. So, the best description is that zuranolone increases chloride channel opening in the presence of GABA, strengthening the inhibitory signal. It does not inhibit GABA binding, block the channels, or activate potassium channels.

Zuranolone is a positive allosteric modulator of GABA-A receptors. The GABA-A receptor is a ligand-gated chloride channel; when GABA binds, the channel opens and chloride ions enter the neuron, producing inhibition. Zuranolone binds to an allosteric site and increases the probability (or duration) that the channel opens in response to GABA. This boosts chloride influx and enhances GABAergic inhibition. So, the best description is that zuranolone increases chloride channel opening in the presence of GABA, strengthening the inhibitory signal. It does not inhibit GABA binding, block the channels, or activate potassium channels.

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