The SGLT2 transporter co-transports which substances?

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Multiple Choice

The SGLT2 transporter co-transports which substances?

Explanation:
Sodium and glucose reabsorption in the proximal tubule is carried out by the SGLT2 transporter as a sodium-glucose co-transport mechanism. It uses the sodium gradient, established by the Na+/K+ ATPase on the basolateral membrane, to move glucose from the tubular lumen into the epithelial cell together with sodium. Once inside the cell, glucose exits to the blood via facilitative GLUT transporters. This coupling means SGLT2 specifically transports sodium alongside glucose, not potassium, chloride, calcium, or phosphate. Inhibiting SGLT2 reduces glucose reabsorption (and also sodium reabsorption) leading to glucosuria and natriuresis, which is the basis for SGLT2 inhibitor drugs.

Sodium and glucose reabsorption in the proximal tubule is carried out by the SGLT2 transporter as a sodium-glucose co-transport mechanism. It uses the sodium gradient, established by the Na+/K+ ATPase on the basolateral membrane, to move glucose from the tubular lumen into the epithelial cell together with sodium. Once inside the cell, glucose exits to the blood via facilitative GLUT transporters. This coupling means SGLT2 specifically transports sodium alongside glucose, not potassium, chloride, calcium, or phosphate. Inhibiting SGLT2 reduces glucose reabsorption (and also sodium reabsorption) leading to glucosuria and natriuresis, which is the basis for SGLT2 inhibitor drugs.

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