The primary receptor targeted by zuranolone is which?

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Multiple Choice

The primary receptor targeted by zuranolone is which?

Explanation:
Zuranolone works by modulating the GABA-A receptor, the main receptor mediating inhibitory signaling in the brain. As a positive allosteric modulator, it enhances the effect of GABA at this receptor, increasing chloride influx, hyperpolarizing neurons, and dampening neural excitability. This boost in inhibitory signaling can produce rapid mood- and anxiety-related benefits. Other receptors like NMDA (involved in different rapid-acting antidepressants), or dopamine and opioid receptors, are not the primary targets of zuranolone. So the primary receptor targeted is the GABA-A receptor.

Zuranolone works by modulating the GABA-A receptor, the main receptor mediating inhibitory signaling in the brain. As a positive allosteric modulator, it enhances the effect of GABA at this receptor, increasing chloride influx, hyperpolarizing neurons, and dampening neural excitability. This boost in inhibitory signaling can produce rapid mood- and anxiety-related benefits. Other receptors like NMDA (involved in different rapid-acting antidepressants), or dopamine and opioid receptors, are not the primary targets of zuranolone. So the primary receptor targeted is the GABA-A receptor.

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