The component that disrupts nasal tight junctions in Neffy is?

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Multiple Choice

The component that disrupts nasal tight junctions in Neffy is?

Explanation:
Nasal absorption relies on the barrier created by tight junctions between epithelial cells. To boost permeability for certain drugs, clinicians use absorption enhancers that temporarily loosen these junctions, increasing paracellular transport. In Neffy, the component that does this is Intravail, a nasal permeation enhancer designed to disrupt tight junctions and momentarily increase mucosal permeability, allowing rapid systemic uptake of the drug. The other substances listed serve different roles—sucralfate protects the mucosa, dextran is a bulky sugar, and saline is just a vehicle—so they do not disrupt tight junctions.

Nasal absorption relies on the barrier created by tight junctions between epithelial cells. To boost permeability for certain drugs, clinicians use absorption enhancers that temporarily loosen these junctions, increasing paracellular transport. In Neffy, the component that does this is Intravail, a nasal permeation enhancer designed to disrupt tight junctions and momentarily increase mucosal permeability, allowing rapid systemic uptake of the drug. The other substances listed serve different roles—sucralfate protects the mucosa, dextran is a bulky sugar, and saline is just a vehicle—so they do not disrupt tight junctions.

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