SGLT2 is located where?

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Study for the Pharmacology Presentation Drugs Test. Delve into flashcards and multiple choice questions with hints and explanations. Gear up for examination success!

Multiple Choice

SGLT2 is located where?

Explanation:
SGLT2 sits in the proximal tubule of the kidney, where it reabsorbs the majority of filtered glucose back into the bloodstream. Specifically, it’s on the apical surface of proximal tubule cells in the early segment (S1/S2). The glomerulus is the filtration site, not where glucose transporters reclaim glucose. The distal tubule and collecting ducts have different transporters and channels and do not express SGLT2. So the location is the proximal tubules of the nephrons in the kidney. Clinically, blocking SGLT2 with inhibitors reduces glucose reabsorption, leading to more glucose excreted in urine.

SGLT2 sits in the proximal tubule of the kidney, where it reabsorbs the majority of filtered glucose back into the bloodstream. Specifically, it’s on the apical surface of proximal tubule cells in the early segment (S1/S2). The glomerulus is the filtration site, not where glucose transporters reclaim glucose. The distal tubule and collecting ducts have different transporters and channels and do not express SGLT2. So the location is the proximal tubules of the nephrons in the kidney. Clinically, blocking SGLT2 with inhibitors reduces glucose reabsorption, leading to more glucose excreted in urine.

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