Ocrelizumab FAB regions bind to what?

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Multiple Choice

Ocrelizumab FAB regions bind to what?

Explanation:
The Fab region is the part of an antibody that determines what it binds. Ocrelizumab is designed to recognize CD20, a protein found on the surface of B lymphocytes. So its Fab region binds specifically to CD20 on B cells. The other markers—CD3 on T cells, CD34 on stem cells, CD56 on NK cells—are not the targets of ocrelizumab, which is why they aren’t bound by its Fab region. Because it binds CD20, ocrelizumab can deplete B cells through mechanisms like antibody-dependent cellular cytotoxicity and complement activation, which explains its therapeutic use in diseases such as multiple sclerosis.

The Fab region is the part of an antibody that determines what it binds. Ocrelizumab is designed to recognize CD20, a protein found on the surface of B lymphocytes. So its Fab region binds specifically to CD20 on B cells. The other markers—CD3 on T cells, CD34 on stem cells, CD56 on NK cells—are not the targets of ocrelizumab, which is why they aren’t bound by its Fab region. Because it binds CD20, ocrelizumab can deplete B cells through mechanisms like antibody-dependent cellular cytotoxicity and complement activation, which explains its therapeutic use in diseases such as multiple sclerosis.

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