Neffy is formulated with epinephrine and which component?

• A. Guaifenesin
• B. Intravil (disrupts tight junctions in nose)
• C. Diphenhydramine
• D. Theophylline

Answer: (B)

The main idea is that intranasal delivery of epinephrine in Neffy relies on a permeation enhancer to boost absorption through the nasal mucosa. Epinephrine alone doesn’t pass well across the nasal lining, so Neffy includes an absorption enhancer that temporarily opens tight junctions between nasal cells, allowing epinephrine to enter the bloodstream quickly.

The best choice is the component known as the permeation enhancer Intravail, which disrupts tight junctions in the nose to increase mucosal absorption. The other listed ingredients do not serve this role: guaifenesin is an expectorant, diphenhydramine is an antihistamine, and theophylline is a bronchodilator, none of which are used to enhance intranasal absorption of epinephrine.