How is Ocrelizumab administered?

• A. Oral tablets daily
• B. IV, first two doses are half, and then rest are full
• C. Subcutaneous injections weekly
• D. Intramuscular injections monthly

Answer: (B)

Ocrelizumab is a monoclonal antibody given by intravenous infusion, not by mouth, because large protein drugs aren’t effectively absorbed orally and must be infused to monitor for infusion reactions. The typical schedule starts with two 300 mg infusions about two weeks apart to start B-cell depletion safely, then maintenance infusions of 600 mg every 6 months. That pattern matches the description of initial half-dose infusions followed by full-dose maintenance.