ATTR-CM primarily involves which organ?

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Multiple Choice

ATTR-CM primarily involves which organ?

Explanation:
Transthyretin amyloid cardiomyopathy (ATTR-CM) centers on the deposition of transthyretin-derived amyloid in the heart muscle. This buildup makes the myocardium stiff, leading to diastolic dysfunction and a restrictive cardiomyopathy pattern. While amyloid can affect multiple organs in systemic forms, ATTR-CM is defined by its primary and prominent involvement of the heart, producing symptoms of heart failure with preserved ejection fraction and characteristic imaging findings. So the organ most affected is the heart.

Transthyretin amyloid cardiomyopathy (ATTR-CM) centers on the deposition of transthyretin-derived amyloid in the heart muscle. This buildup makes the myocardium stiff, leading to diastolic dysfunction and a restrictive cardiomyopathy pattern. While amyloid can affect multiple organs in systemic forms, ATTR-CM is defined by its primary and prominent involvement of the heart, producing symptoms of heart failure with preserved ejection fraction and characteristic imaging findings. So the organ most affected is the heart.

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